Your knee hurts because it's injured. You really need to figure out what is wrong and correct that. Backing off meanwhile might be a good idea until you can run pain free. The extra weight doesn't help but it probably isn't the cause. There are others who post here who can give you a better idea of the medical reasons for your pain. You will need to describe, precisely, where it hurts (e.g. behind the kneecap, below it, above, near one corner, on the outside (lateral side) of the knee, etc.) and under what circumstances it hurts (running only, walking, upstairs, downstairs, pressure in particular directions, and so on). This info gives a much better idea of what the problem is and what steps to take to fix it. But for starters, make sure you are not using old shoes, or shoes that are not suited to running (like old gym shoes). A visit to a good running store to be fitted for shoes might help.
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